Medicinal Chemistry Basics (All you need to know)

Binding assays provide useful information with regard to the ability of compounds to bind to a receptor, essentially no information is pr...

KINDS OF ASSAYS:   ENZYME / RECEPTOR BASED ASSAYS (ALSO CALLED AS BINDING ASSAYS), CELL BASED ASSAYS (FUNCTIONAL ASSAYS) https://www.s...

ü Understanding of in vitro-in vivo correlation and frontloading PK/PD is crucial for the compound selection even at an early stage.  ...

v   Prior to clinical trials a new chemical entities’ (NCE’s) pre-clinical pharmacokinetics should be determined.   Once the test compoun...

As discussed earlier, mouse models are more attractive than big animal models because of the low cost, ease-of-handling and known genetic...