Before defining efficacy – let us understand that
there are couple of other terms which go hand in hand with the word ‘efficacy’ –
they are ‘potency’ and ‘effectiveness’.
- Say ’50 mg’ amount of a drug A is needed to alleviate a condition; now ‘100 mg’ amount of drug B is needed to alleviate the same condition. Without any confusion we can say that drug A is more potent than drug B.
- Let us say, same amount of drug A and drug B are taken separately for a condition (by a patient with one and only one problem/condition, ideal subject). If drug A completes the job to alleviate the condition, however drug B partially alleviates the condition then we can say that drug A is more efficacious than drug B. [Efficacy: maximum response achievable from a drug or to the capacity for sufficient therapeutic effect/beneficial change. Therefore, efficacy trials determine whether an intervention produces the expected result under ideal circumstances]
- Efficacious drugs cannot always be effective. No confusion please. Because effectiveness refers to ‘’how drug works in a real-world situation’.
(1) Efficacious drug for a symptom should not have
side effects and thus can become an effective drug. For example, say we have a highly efficacious
drug for certain condition – but it also has so many side effects. Then we can say that this drug’s
effectiveness is lower than its efficacy.
(2) in the real world, the drug administered to a
patient has to interact with other medications taken by patient; depends on
health conditions of the patient; patient might not follow the prescribed dose
or duration by the physician etc.
Therefore effectiveness is
always lower than efficacy.
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